Amongst the OTCs, Benadryl and Tylenol take the top positions because of how safe they are to use and the effect they produce. Benadryl is known to relieve allergic symptoms, whereas latter relieves pain which further aids in easing discomfort. But can you take Benadryl and Tylenol together?

The good news is that it is safe to take both Tylenol and Benadryl together at once. As a matter of fact, some of the brands incorporate both active ingredients, diphenhydramine as well as acetaminophen in one for max effects.

What Are Tylenol and Benadryl, and can You Mix Them?

Both drugs are available over the counter and are combined to use together. Benadryl does not interact with Tylenol making them pretty compatible with one another.

Acetaminophen and diphenhydramine combo is fit to treat occasional insomnia associated with not much severe pain and discomfort. Even though diphenhydramine or Benadryl has sedative effects, it is not helpful to treat sleeplessness that is not connected to pain or sleep disorders.

During an allergy attack or cold, with classic symptoms, minor aches and pains like headache and back pain, along with joint plus muscle, start to hurt, which can be treated with the mix.

How Can You Take Benadryl with Tylenol?

Your pharmacist can give a better answer to this. However, if you can’t get a hold of one, the rule of thumb is to follow the instructions of use printed on the label. The capsule or tablet is usually taken with a glass of water.

You should know that both the medicines of the subject are for short-term use until the symptoms ease off.

Always make sure to abide by the recommended dose and not go overboard. If one overdoses on acetaminophen, it will obstruct the liver or can result in fatality. At the same time, intake of too much diphenhydramine can cause serious heart problems, coma, seizures, or even death.


Do not use both of these medicines in anyone younger than 12 years of age. Moreover, do not try using its sedative effect to put your child to sleep.

Tylenol and Benadryl are not apt for use longer than 2 weeks times to treat mild sleep troubles or longer than 7 days for getting rid of cold or allergy symptoms.

If your condition does not improve, get in touch with your physician or pharmacist.

Side effects of Tylenol and Benadryl If Taken Together?

Antihistamine (diphenhydramine) is supposed to treat allergic responses and not cause one. If you see hives emerging or sudden difficulty in breathing, call for emergency help.

In rare circumstances, Tylenol use can result in severe skin reactions that may turn fatal. You should discontinue use immediately in case of the following:

  • Increased sleepiness or sedation effect
  • Discomfort or burning sensation while urination
  • Liver troubles
  • Loss of appetite
  • Abdominal pain
  • Fatigue
  • Skin itch
  • Dark-colored urine output

A few common side effects include:

  • Constipation;
  • Low urine output
  • Dry, Itchy eyes
  • Blurred vision
  • Dry oral cavity

Final Words

Tylenol and Benadryl work perfectly well together. All one needs to do is keep a check on allergy symptoms and whether or not they take other medicines for a health condition. Pharmacists at Rxology can be of help.

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